Exosomes in aesthetic medicine and dermatology: A review and clinical experience

Exosomes are microscopic particles secreted by various plant and animal cells, including human cells. They carry valuable biologically active substances such as proteins, lipids, nucleic acids, and metabolites that exert beneficial effects on various structures and tissues. In aesthetic medicine and dermatology, exosomes have attracted attention due to their ability to enhance collagen synthesis, eliminate inflammation, and improve the skin’s protection against harmful external factors. To date, considerable clinical experience has been gained in the use of exosome products for the treatment of skin diseases such as rosacea, acne, pigmentation disorders, and alopecia, as well as for aesthetic correction and skin rejuvenation. When using exosomes, it is important to have an understanding of the origin of a particular product, including the manufacturer, the production and analysis standards used, due to the lack of international standardization in this area. For the most effective implementation of exosome-based treatments, adherence to official directions for use is critical. With no unified application protocols available, the evaluation of specialists’ practical experience in this area is particularly valuable. This article presents a general overview of exosomes, discusses their production and analysis on an industrial scale, and describes the current state of their application in clinical practice. In addition, the experience of exosomal therapy in dermatology and aesthetic medicine is presented.