Acute vette leverziekte van de zwangerschap (AFLDP): bijkomende klinische expressies

Acute fatty liver disease of pregnancy (AFLDP): other clinical expressions Newly emergent liver diseases during pregnancy, such as intrahepatic cholestasis (ICP), the HELLP syndrome (hemolysis, elevated liver enzymes, low platelets) and acute fatty liver disease of pregnancy (AFLDP), exhibit significant overlap in both pathophysiology and clinical presentation. Although ICP and the HELLP syndrome usually have a self-limiting course, AFLDP can lead to severe complications such as liver failure and maternal death, emphasizing the need for multidisciplinary care and transfer to an intensive care setting. The Swansea criteria, developed in 2002, assist in diagnosing AFLDP, but their reliability and completeness are still under discussion. In this case report, we discuss a 21-year-old woman with AFLDP at 34 weeks of pregnancy. The patient exhibited symptoms such as anorexia, polydipsia and liver function disturbances, meeting 10 of the 14 Swansea criteria. Postpartum complications included hypertension, encephalopathy, renal insufficiency and transient pituitary failure, highlighting the complexity of AFLDP as a multisystem disease. Our case illustrates the need for continuous multidisciplinary follow-up and shows that current diagnostic criteria for AFLDP require further refinement. We advocate for the establishment of an international database to improve the diagnosis and treatment of AFLDP and to gain more insight into the variability and severity of this condition.