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October 2, 2025MedicinaOpen Access

A Mixed Model of Clinical Characteristics, Strain Elastography and ACR-TIRADS Predicts Malignancy in Small Thyroid Nodules: A Prospective Single-Center Study

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Authors

NANicholas AngelopoulosEPEmmanouil PetropoulosICIoannis Chrisogonidis

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Overview

Prospective study identifies clinical characteristics and elastography scores as key predictors of malignancy in thyroid nodules, suggesting improved diagnostic approaches.

Key Points

  • A mixed model combining clinical characteristics and ACR scoring achieved perfect performance, indicating high accuracy in predicting malignancy.
  • Logistic regression analysis demonstrated ACR-scoring as a significant predictor of FNA results, with an area under the curve of 0.993.
  • Patients with Bethesda V–VI results exhibited higher autoimmune thyroiditis rates and ACR scoring points compared to those with Bethesda II.
  • The study assessed 141 patients with thyroid nodules, showing that the mixed model effectively stratifies those needing further evaluation.

Cite This Study

Angelopoulos et al. (2025) studied this question.

synapsesocial.com/papers/68de68e583cbc991d0a21100https://doi.org/10.3390/medicina61101774
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