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August 2, 2026CureusOpen Access

Comparison of the Diagnostic Performance of ACR TI-RADS and EU-TI-RADS for the Detection of Thyroid Malignancy: A Retrospective Study

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Authors

AAAbdelwahed Samir AbougaziaPrimary Health CareBABan AbdullahPrimary Health CareAAAhmed AbdelmoneimHamad Medical Corporation

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Overview

Retrospective study compares ACR TI-RADS and EU-TI-RADS for thyroid malignancy detection, suggesting implications for diagnostic accuracy.

Key Points

  • This study aims to compare the diagnostic performance of ACR TI-RADS and EU-TI-RADS in distinguishing malignant from benign thyroid nodules using guideline-based fine-needle aspiration recommendations.
  • Retrospective analysis of 809 thyroid nodules assessed by ultrasound and ultrasound-guided fine-needle aspiration cytology.
  • Diagnostic performance evaluated using a variety of statistics including sensitivity, specificity, and overall accuracy.
  • Multivariable logistic regression identified independent predictors of malignancy based on sonographic characteristics.
  • ACR TI-RADS correctly identified 135 out of 157 malignant nodules (sensitivity 85.99%) and 481 out of 652 benign nodules (specificity 73.77%).
  • EU-TI-RADS correctly identified 142 out of 157 malignant nodules (sensitivity 90.45%) but only 233 out of 652 benign nodules (specificity 35.74%).
  • ACR TI-RADS demonstrated superior overall accuracy (76.14% vs 46.35%) and positive predictive value (44.12% vs 25.31%) compared to EU-TI-RADS.

Cite This Study

Abougazia et al. (2026) studied this question.

synapsesocial.com/papers/6a6eeaa21b0468a7eeab2e49https://doi.org/10.7759/cureus.113675
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diagnostic performance of the ACR TI-RADS classification in identifying and excluding thyroid malignancy: a multi-correlative retrospective study in a South African tertiary hospital2025
  2. 2Correlation of ACR TI-RADS ultrasound classification with cytopathology: a retrospective evaluation of diagnostic accuracy2026
  3. 3Comparison of ACR TI-RADS and ATA Ultrasound Risk Stratification for Thyroid Nodules – Data from a Tertiary Hospital in the United Arab Emirates2026
  4. 4Diagnostic performance of the ACR TI-RADS classification in identifying and excluding thyroid malignancy: A multi-correlative retrospective study in a South African tertiary hospital2025
  5. 5Correlation Between the Thyroid Imaging Reporting and Data System and Bethesda System of Cytology in Thyroid Nodule Evaluation2024