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This is a Quantitative Study study (also classified as: Experimental Study).

October 2, 2025BacteriaOpen Access

Antitumor Potential of Bioactive Crude Extracts Derived from Actinomycetes

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This analysis shows promising antitumor activity in Caco-2 and HepG-2 cells, indicating marine actinomycetes may be key in cancer treatment.

Bioactive extracts significantly reduced cell viability to 24–37% in Caco-2 cells and 12–25% in HepG-2 cells.
The extracts exhibited IC50 values ranging from 1.72 to 3.53 µg/µL depending on the extract and cell type.
Western blot analysis revealed notable increases in the Bax/Bcl-2 ratio and p53 protein expression in response to treatment.
These findings imply marine actinomycetes could be developed into effective antitumor agents targeting apoptosis pathways.

Dhaini et al. (2025) studied this question.

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October 2, 2025BacteriaOpen Access

View Full Paper

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Authors

This analysis shows promising antitumor activity in Caco-2 and HepG-2 cells, indicating marine actinomycetes may be key in cancer treatment.

Bioactive extracts significantly reduced cell viability to 24–37% in Caco-2 cells and 12–25% in HepG-2 cells.
The extracts exhibited IC50 values ranging from 1.72 to 3.53 µg/µL depending on the extract and cell type.
Western blot analysis revealed notable increases in the Bax/Bcl-2 ratio and p53 protein expression in response to treatment.
These findings imply marine actinomycetes could be developed into effective antitumor agents targeting apoptosis pathways.

Dhaini et al. (2025) studied this question.

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