This analysis reveals the release mechanisms of protein molecules in pH-sensitive systems, indicating their efficacy in drug delivery.
The degree of bovine serum albumin (BSA) released from particles based on chitosan and hydroxyapatite prepared by encapsulation and chemisorption methods, crosslinked by aldol condensation, was studied. The obtained materials’ composition was qualitatively determined by IR spectroscopy; phase identification and surface morphology were analyzed by X-ray diffraction and scanning electron microscopy, respectively. A spectrophotometric method was used to quantitatively assess the loading and release degree of encapsulated/chemisorbed BSA from polymer microspheres. To determine the release mechanism, the data on the amount of BSA released were analyzed according to the zero- and first-order, Higuchi, and Korsmayer–Peppas models.
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Chernikova et al. (2025) studied this question.
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