Virtual screening identified potential inhibitors targeting dihydrofolate reductase in Mycobacterium tuberculosis, indicating new anti-tuberculosis drug candidates.
Mycobacterium tuberculosis is a distinct gram-positive bacterium causing tuberculosis. For novel anti-tuberculosis drug discovery, virtual screening and machine learning was employed targeting dihydrofolate reductase in folate biosynthetic pathway.
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Halder et al. (2025) studied this question.
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