Observational study finds xenotransplantation efficiency varies with tumor sampling site in gastric cancer, suggesting tumor edge samples may enhance success.
Key Points
Xenotransplantation efficiency was 84% when samples were taken from tumor edges.
Only 20% efficiency was observed for samples gathered from more than 5 mm away from the tumor edge.
Histological examination confirmed the adenocarcinoma status of heterotopic PDXs, matching donor tumors.
Ki-67 expression was significantly higher in tumor edges (average 70%) versus non-marginal regions (average 15%).