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October 2, 2025Applied Science and Engineering Progress

CNC Milling and CO2 Laser Engraving of Mixing Microchannels in Microfluidic Devices

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Authors

ZNZachary NgoCCCatherine Joy CancinoJDJedrek Carl Dy

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Overview

This comparison reveals that CNC milling improves fluid flow in microfluidic devices, indicating better fabrication precision and efficiency than CO2 laser engraving.

Key Points

  • CNC milling achieved greater microchannel precision, enhancing fluid flow characteristics, and mixing efficiency in microfluidic devices.
  • Polymethyl methacrylate (PMMA) proved to be the most cost-effective material while maintaining ideal optical and mechanical properties for microfluidic applications.
  • Fabrication was completed using Autodesk Fusion for CNC milling and RDWorks V8 for laser setup, with a focus on material compatibility.
  • This study underscores the importance of selecting the right fabrication technique to optimize microfluidic device performance and minimize costs.

Cite This Study

Ngo et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21908https://doi.org/10.14416/j.asep.2025.10.001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Fabrications of Low-Cost Poly(methyl methacrylate) Microfluidic Devices for Precise Passive Flow Control2024
  2. 2Evaluating Laser‐Based Microfabrication in Microfluidics: An Experimental and Computational Trial2024 · 1 citations
  3. 3Polymer Micro-Milling for Cost-Effective Microfluidic and Biosensor Chip Fabrication: A Review2026 · 1 citations
  4. 4An Alternative Micro-Milling Fabrication Process for Rapid and Low-Cost Microfluidics2024 · 10 citations
  5. 55-axis CNC micro-milling machine for three-dimensional microfluidics2024