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October 1, 2025Open Access

Figure S9 from Spatial Analysis of the Tumor Microenvironment in Diffuse Large B-cell Lymphoma Reveals Clinically Relevant Cell Interactions and Recurrent Cellular Neighborhoods

Matias Autio Suvi‐Katri Leivonen Leo Meriranta Marja‐Liisa Karjalainen‐Lindsberg Teijo Pellinen Sirpa Leppä

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Key Points

Significant interactions between B cells and PD-1+ T cells impact lymphoma behavior and cell organization.
The study identifies recurrent cellular neighborhoods that are critical for understanding tumor dynamics in diffuse large B-cell lymphoma.
Spatial analysis depicts how B cells are both attracted to and avoiding PD-1+ T cells, suggesting a complex relationship in the tumor microenvironment.
Further exploration of these cell interactions could lead to improved therapeutic strategies in managing diffuse large B-cell lymphoma.

Implication

Spatial analysis reveals B and T cell interactions in diffuse large B-cell lymphoma, indicating relevant cellular dynamics.

Abstract

Proportion of B cells and T cells in lymphomas where B cells are avoiding and attracted to PD-1+ T cells.

Discussion

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Cite This Study

Autio et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2191c https://doi.org/10.1158/2326-6066.30255790

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S6 from Spatial Analysis of the Tumor Microenvironment in Diffuse Large B-cell Lymphoma Reveals Clinically Relevant Cell Interactions and Recurrent Cellular Neighborhoods2025
2Figure S12 from Spatial Analysis of the Tumor Microenvironment in Diffuse Large B-cell Lymphoma Reveals Clinically Relevant Cell Interactions and Recurrent Cellular Neighborhoods2025
3Figure S15 from Spatial Analysis of the Tumor Microenvironment in Diffuse Large B-cell Lymphoma Reveals Clinically Relevant Cell Interactions and Recurrent Cellular Neighborhoods2025
4Figure S14 from Spatial Analysis of the Tumor Microenvironment in Diffuse Large B-cell Lymphoma Reveals Clinically Relevant Cell Interactions and Recurrent Cellular Neighborhoods2025
5Figure S1 from Spatial Analysis of the Tumor Microenvironment in Diffuse Large B-cell Lymphoma Reveals Clinically Relevant Cell Interactions and Recurrent Cellular Neighborhoods2025