Supplementary Figure S6 from Increased Peripheral T Stem Cell–like Memory Features in Patients with Advanced Solid Tumors Treated with Tumor-Targeting IL-12 Immunocytokine Therapy

Q: What type of study is this?

This is a Experimental Study study.

Meghali Goswami; Carolina Celades; Christine M. Minnar; Asma S. Khelifa; Lisa K. Poppe; Dara Bracken-Clarke; Nicole J. Toney; Megan T. Lynch; Jennifer L. Marté; Sofia R. Gameiro; James L. Gulley; Jeffrey Schlom; Renee N. Donahue

doi:10.1158/1078-0432.30255752

October 1, 2025

Supplementary Figure S6 from Increased Peripheral T Stem Cell–like Memory Features in Patients with Advanced Solid Tumors Treated with Tumor-Targeting IL-12 Immunocytokine Therapy

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Key Points

The treatment resulted in notable increases in memory features of CD4+ T cells, indicating enhanced immune response.
Patients demonstrated significant changes in CD4+ T cell fractions before and during therapy, with specific clustering observed.
High dimensional clustering analysis was applied to assess the CD4+ T cell response in advanced solid tumor patients undergoing treatment.
These findings suggest potential implications for improving immunotherapy approaches in solid tumors.

Implication

High dimensional clustering of CD4+ T cells shows changes during tumor-targeting IL-12 therapy in patients with advanced solid tumors.

Abstract

Supplementary Figure 6. High dimensional clustering of CD4+ T cell fraction in patients with advanced solid tumors before and during PDS01ADC therapy.

Discussion

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Cite This Study

Goswami et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21938 https://doi.org/10.1158/1078-0432.30255752

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Supplementary Figure S6 from Increased Peripheral T Stem Cell–like Memory Features in Patients with Advanced Solid Tumors Treated with Tumor-Targeting IL-12 Immunocytokine Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S6 from Increased Peripheral T Stem Cell–like Memory Features in Patients with Advanced Solid Tumors Treated with Tumor-Targeting IL-12 Immunocytokine Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

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