Supplementary Figure S2 from Increased Peripheral T Stem Cell–like Memory Features in Patients with Advanced Solid Tumors Treated with Tumor-Targeting IL-12 Immunocytokine Therapy

Q: What type of study is this?

This is a Quantitative Study study.

Meghali Goswami; Carolina Celades; Christine M. Minnar; Asma S. Khelifa; Lisa K. Poppe; Dara Bracken-Clarke; Nicole J. Toney; Megan T. Lynch; Jennifer L. Marté; Sofia R. Gameiro; James L. Gulley; Jeffrey Schlom; Renee N. Donahue

doi:10.1158/1078-0432.30255764

October 1, 2025Open Access

Supplementary Figure S2 from Increased Peripheral T Stem Cell–like Memory Features in Patients with Advanced Solid Tumors Treated with Tumor-Targeting IL-12 Immunocytokine Therapy

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Key Points

Patients treated with IL-12 therapy show increased T stem cell-like memory features.
The study reveals distinct gating strategies for CD8+ and CD4+ T cells in peripheral blood.
Gating techniques were validated using fluorescence-minus-one controls for accurate measurement.
These findings may suggest new approaches for enhancing immune responses in cancer therapy.

Implication

Analysis reveals enhanced T stem cell characteristics in peripheral blood of patients treated with IL-12 immunocytokine therapy.

Abstract

Supplementary Figure 2. Gating strategy of human TSCM. (A) Gating of human CD8+ TSCM cells in peripheral blood. The same gating scheme was applied to CD4+ cells. (B) Dot plots of CD8+ cells from representative healthy donor across indicated fluorescence-minus-one (FMO) controls, used in the setting of gates.

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Cite This Study

Goswami et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21947 https://doi.org/10.1158/1078-0432.30255764

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Supplementary Figure S2 from Increased Peripheral T Stem Cell–like Memory Features in Patients with Advanced Solid Tumors Treated with Tumor-Targeting IL-12 Immunocytokine Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S2 from Increased Peripheral T Stem Cell–like Memory Features in Patients with Advanced Solid Tumors Treated with Tumor-Targeting IL-12 Immunocytokine Therapy

Key Points

Implication

Abstract

Discussion

Cite This Study

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