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October 2, 2025

Supplementary Figure S5 from Targeting Myeloid Trem2 Reprograms the Immunosuppressive Niche and Potentiates Checkpoint Immunotherapy in NASH-Driven Hepatocarcinogenesis

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Authors

ZWZiyi WangYZYu ZhangXLXiangdong Li

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Overview

Targeting Trem2 reconfigures the immunosuppressive niche and improves checkpoint immunotherapy outcomes in NASH, indicating novel therapeutic strategies.

Key Points

  • Accumulation of monocytes and pro-inflammatory macrophages leads to increased degradation of NETs, enhancing therapeutic response.
  • This reprogramming by Trem2Δmye significantly alters the immunosuppressive tumor environment, indicating a potential treatment pathway.
  • Experimental models demonstrate that targeting Trem2 can boost the effectiveness of checkpoint immunotherapy in liver cancer.
  • Treatments could reshape the microenvironment in hepatocarcinogenesis, offering new insights for cancer immunotherapy approaches.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a2196chttps://doi.org/10.1158/2326-6066.30255481
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