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October 1, 2025

Supplementary Figure S4 from A Phase I Trial of Evorpacept, Lenalidomide, and Rituximab for Patients with B-Cell Non-Hodgkin Lymphoma

Paolo Strati Lei Feng Andrey Tyshevich Darya Shavronskaya Julia Alesse Noel English Elizabeth Sheehan Nikita Syzrantsev Alexander Nesmelov Tony Zhuang Dai Chihara Jason R. Westin Sairah Ahmed Luis Fayad Jared Henderson Karin M. Dent Elizabeth McChesney Sattva S. Neelapu Christopher R. Flowers

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Key Points

The trial explores evorpacept’s role alongside lenalidomide and rituximab in treating B-cell non-Hodgkin lymphoma.
Key findings from the UMAP analysis of single cell RNA sequencing support this treatment combination.
This analysis shows single cell RNA sequencing revealing treatment efficacy in B-cell non-Hodgkin lymphoma.
The trial emphasizes the need for further exploration of combinations in lymphoma treatment.

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Implication

Phase I trial evaluates evorpacept with lenalidomide and rituximab for B-cell non-Hodgkin lymphoma, suggesting potential benefits.

Abstract

UMAP from single cell RNA sequencing

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Cite This Study

Strati et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a52 https://doi.org/10.1158/1078-0432.30255113

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S2 from A Phase I Trial of Evorpacept, Lenalidomide, and Rituximab for Patients with B-Cell Non-Hodgkin Lymphoma2025
2Supplementary Figure S1 from A Phase I Trial of Evorpacept, Lenalidomide, and Rituximab for Patients with B-Cell Non-Hodgkin Lymphoma2025
3Supplementary Figure S3 from A Phase I Trial of Evorpacept, Lenalidomide, and Rituximab for Patients with B-Cell Non-Hodgkin Lymphoma2025
4Data from A Phase I Trial of Evorpacept, Lenalidomide, and Rituximab for Patients with B-Cell Non-Hodgkin Lymphoma2025
5Supplementary Protocol S1 from A Phase I Trial of Evorpacept, Lenalidomide, and Rituximab for Patients with B-Cell Non-Hodgkin Lymphoma2025