Supplementary Figure S15 from PSMA-Targeted Small Molecule–Drug Conjugates Based on a Postprolyl Peptidase–Cleavable Linker for the Treatment of Prostate Cancer

Q: What type of study is this?

This is a In Vitro Study study.

Tony Georgiev; Sara Puglioli; Lucrezia Principi; Ettore Gilardoni; Christian Pellegrino; Gabriele Bassi; Andrea Galbiati; Dario Neri; Samuele Cazzamalli

doi:10.1158/1535-7163.30255242

October 1, 2025

Supplementary Figure S15 from PSMA-Targeted Small Molecule–Drug Conjugates Based on a Postprolyl Peptidase–Cleavable Linker for the Treatment of Prostate Cancer

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Key Points

Mouse serum samples were used to analyze the stability of OncoPSMA-GlyPro-MMAE and OncoPSMA-GlyPro-MMAF.
OncoPSMA-GlyPro-MMAE demonstrated in vitro stability, suggesting its viability for therapeutic use in prostate cancer.
Human serum stability studies indicated the potential effectiveness of PSMA-targeted drug conjugates in cancer treatment.
Further research is needed to explore the clinical implications of drug conjugate stability findings in patients.

Implication

In vitro stability tests showed the performance of OncoPSMA-GlyPro-MMAE and OncoPSMA-GlyPro-MMAF in serum, indicating potential efficacy in prostate cancer therapies.

Abstract

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Discussion

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Cite This Study

Georgiev et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a66 https://doi.org/10.1158/1535-7163.30255242

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Supplementary Figure S15 from PSMA-Targeted Small Molecule–Drug Conjugates Based on a Postprolyl Peptidase–Cleavable Linker for the Treatment of Prostate Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S15 from PSMA-Targeted Small Molecule–Drug Conjugates Based on a Postprolyl Peptidase–Cleavable Linker for the Treatment of Prostate Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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