Figure S9 from A Novel Squaramide Derivative, HR-19011, Induces the Integrated Stress Response via the HRI–eIF2α–ATF4 Pathway, Effectively Inhibiting Hematologic Malignancies

Q: What type of study is this?

This is a Experimental Study study.

Min-Jung Kim; Jinsook Kwak; Hyung Seok Kim; Jihyung Han; Ji An Kang; Jeyun Jo; Jisu Kim; Da Jung Kim; Ho Sup Lee; Hwayoung Yun; Jee‐Yeong Jeong

doi:10.1158/1535-7163.30255001

October 1, 2025

Figure S9 from A Novel Squaramide Derivative, HR-19011, Induces the Integrated Stress Response via the HRI–eIF2α–ATF4 Pathway, Effectively Inhibiting Hematologic Malignancies

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Key Points

HR-19011 effectively inhibits hematologic malignancies through stress response activation.
The integrated stress response pathway, especially HRI-eIF2α-ATF4, is crucial in this process.
K562 cells were used to demonstrate the mechanism of action of HR-19011.
Findings indicate a promising approach for treating blood cancers.

Implication

This research demonstrates HR-19011 activates the integrated stress response in K562 cells, suggesting a potential therapeutic strategy for hematologic malignancies.

Abstract

Schematic representation of the proposed mechanism of action of HR-19011 in K562 cells

Discussion

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Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21ad1 https://doi.org/10.1158/1535-7163.30255001

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Figure S9 from A Novel Squaramide Derivative, HR-19011, Induces the Integrated Stress Response via the HRI–eIF2α–ATF4 Pathway, Effectively Inhibiting Hematologic Malignancies

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S9 from A Novel Squaramide Derivative, HR-19011, Induces the Integrated Stress Response via the HRI–eIF2α–ATF4 Pathway, Effectively Inhibiting Hematologic Malignancies

Key Points

Implication

Abstract

Discussion

Cite This Study

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