Figure S8 from A Novel Squaramide Derivative, HR-19011, Induces the Integrated Stress Response via the HRI–eIF2α–ATF4 Pathway, Effectively Inhibiting Hematologic Malignancies

Q: What type of study is this?

This is a In Vitro Study study.

Min-Jung Kim; Jinsook Kwak; Hyung Seok Kim; Jihyung Han; Ji An Kang; Jeyun Jo; Jisu Kim; Da Jung Kim; Ho Sup Lee; Hwayoung Yun; Jee‐Yeong Jeong

doi:10.1158/1535-7163.30255004

October 1, 2025

Figure S8 from A Novel Squaramide Derivative, HR-19011, Induces the Integrated Stress Response via the HRI–eIF2α–ATF4 Pathway, Effectively Inhibiting Hematologic Malignancies

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Key Points

HR-19011 effectively inhibits hematologic malignancies, showcasing its therapeutic potential against blood cancers.
The in vitro kinase assay reveals that HR-19011 does not directly activate HRI, highlighting its unique mechanism of action.
The study explores the role of the integrated stress response pathways involved in the action of HR-19011 on cancer cells.
This findings suggest a novel approach to target hematologic malignancies through specific signaling pathways.

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Implication

In vitro analysis shows HR-19011 inhibits hematologic malignancies by activating the HRI-eIF2α-ATF4 pathway, indicating potential therapeutic avenues.

Abstract

In vitro kinase assay demonstrating that HR-19011 does not directly activate HRI

Discussion

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Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21ad3 https://doi.org/10.1158/1535-7163.30255004

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Figure S8 from A Novel Squaramide Derivative, HR-19011, Induces the Integrated Stress Response via the HRI–eIF2α–ATF4 Pathway, Effectively Inhibiting Hematologic Malignancies

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Figure S8 from A Novel Squaramide Derivative, HR-19011, Induces the Integrated Stress Response via the HRI–eIF2α–ATF4 Pathway, Effectively Inhibiting Hematologic Malignancies

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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