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This is a Cohort Study study (also classified as: Animal Study, Quantitative Study).

October 2, 2025Frontiers in PharmacologyOpen Access

Role of biomarker SOCS1 in peritoneal dialysis-associated peritoneal fibrosis and immune infiltration based on machine learning screening

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SOCS1 was identified as a significant biomarker for peritoneal fibrosis in dialysis patients, revealing its diagnostic potential.
The study found a high area under the curve (AUC) value of 0.914 for SOCS1 and other hub genes, indicating excellent diagnostic accuracy.
Machine learning algorithms effectively screened for fibrosis biomarkers, supported by extensive bioinformatics and clinical validation.
Findings underscore SOCS1's involvement in TGF-β/Smad signaling pathways, linking it to fibrotic processes and immune cell dynamics.

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Bioinformatics identified SOCS1 as a key biomarker in peritoneal fibrosis, highlighting immune infiltration patterns.

Ma et al. (2025) studied this question.

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