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October 2, 2025Frontiers in Cell and Developmental BiologyOpen Access

METTL3-mediated activation of Sonic Hedgehog signaling promotes breast cancer progression

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Authors

SBSunanda BaidyaUBUtpal BaruaMSMuntasim Rahman Shanto

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Overview

Bioinformatic analyses reveal METTL3 overexpression correlates with Sonic Hedgehog signaling, indicating potential therapeutic targets.

Key Points

  • Overexpression of METTL3 significantly correlates with poor patient outcomes in breast cancer.
  • Diverse analyses from patient data and gene expression profiles confirm the connection between METTL3 and Sonic Hedgehog signaling.
  • Statistical tests indicate that METTL3 and SHH pathway components show notable dysregulation in breast cancer patients.
  • Understanding the METTL3-SHH axis offers insights into tumor biology and potential epigenetic treatment avenues.

Cite This Study

Baidya et al. (2025) studied this question.

synapsesocial.com/papers/68de6f3183cbc991d0a21f86https://doi.org/10.3389/fcell.2025.1674339
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