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October 2, 2025Frontiers in PhysiologyOpen Access

Sex hormone-specific regulation of ferroptosis in vascular cells in atherosclerosis: molecular mechanisms and targeted strategies

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Atherosclerosis shows sex differences in progression, with estrogen inhibiting ferroptosis in vascular cells.
Estrogen activates the antioxidant system and regulates iron metabolism, providing cardiovascular protection in women.
Androgens may promote ferroptosis by enhancing oxidative stress and cellular iron uptake in men.
This framework supports novel sex-specific therapeutic strategies in precision cardiovascular medicine.

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This review highlights sex hormones' roles in ferroptosis of vascular cells, suggesting targeted AS therapies for men and women.

Yu et al. (2025) studied this question.

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