This approach improves electrochemical detection of oxidase analytes using oxygen-permeable membranes, suggesting better sensor performance.
The oxygen‐permeable poly(dimethylsiloxane) (PDMS) membrane covered with platinum nanoparticles‐decorated single‐walled carbon nanotubes (PtNP/SWCNT/PDMS) was examined as a biocompatible and transparent gas diffusion electrode sheet for the first‐generation electrochemical biosensor to resolve oxygen depletion at the electrode surface. Due to the oxygen supply to the PtNP‐decorated SWCNT layer through the PDMS membrane, a cathodic current based on the oxygen reduction reaction for PtNP/SWCNT/PDMS was about 5 times larger than that for without oxygen supply through PDMS under an air‐saturated 67 mM phosphate buffer (pH 7.4). In addition, an anodic current of hydrogen peroxide (H 2 O 2 ) oxidation was also observed at the PtNP/SWCNT/PDMS electrode in the phosphate buffer. Based on these results, the PtNP/SWCNT/PDMS electrode modified with oxygen‐dependent oxidase enzymes, such as glucose oxidase (GOx), successfully enabled that upper detection limit of H 2 O 2 produced from the GOx‐catalyzed oxidation of glucose was improved in comparison with that without oxygen supply through PDMS. The PtNP/SWCNT/PDMS electrode sheet would therefore be applied to not only first‐generation electrochemical biosensors but also enzyme‐based biofuel cells with enhanced performance.
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Goto et al. (2025) studied this question.
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