Peripheral circular RNAs hsacirc₀075436 and hsacirc₀005729 as diagnostic and prognostic biomarkers in acute ischemic stroke: expression profiles and mechanistic insights

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Discussion

Analysis reveals two circular RNAs as reliable biomarkers in acute ischemic stroke, indicating their potential role in diagnosis and prognosis.

Hsa_circ_0075436 and hsa_circ_0005729 significantly decreased in patients with acute ischemic stroke.
Receiver operating characteristic analysis indicated strong diagnostic performance for both circular RNAs.
The levels of these circular RNAs negatively correlated with NIH Stroke Scale scores in acute ischemic stroke patients.
Bioinformatics analyses suggest hsa_circ_0005729 influences blood-brain barrier disruption in acute ischemic stroke.

Jiang et al. (2025) studied this question.

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Analysis reveals two circular RNAs as reliable biomarkers in acute ischemic stroke, indicating their potential role in diagnosis and prognosis.