Mangosteen (Garcinia mangostana L.) peel extract potential in controlling blood glucose and HbA1c levels in Balb-C mice by using HPLC

Diabetes mellitus still lacks a perfect therapeutic approach due to the wide variability of its causes and the many complications that occur in people with diabetes mellitus. The management of diabetes mellitus requires a multidisciplinary approach, including pharmacological and non-pharmacological therapies. Mangosteen peel contains Xanthone, which is believed to reduce blood glucose levels or act as an antihyperglycemic. One of the non-pharmacological treatments is the use of mangosteen peel extract. This study investigates the effects of mangosteen peel extract on blood glucose and HbA1c levels in Balb-C mice, aiming to determine whether it can reduce blood glucose and function as an antihyperglycemic agent. The study was designed with a pre-test/post-test to control groups, extracting mangosteen rind and inducing Balb/c mice using alloxan. Each group consisted of 4 mice; the total number of mice to be studied was 25. To account for the dropout, the HbA1c levels were measured using HPLC techniques. There was an effect of mangosteen peel extract on blood glucose levels of Balb-C and HbA1c mice with a significance value of 0.018 <0.05 and a significance value of 0.010 <0.05, respectively. The most effective dose identified in the study is V5 with a dose of 500 mg.