Development of a Transdermal Formulation of Chrysanthemum Indicum Extract for Antimicrobial and Anti?Inflammatory Applications

Nowadays there is an increasing demand of the herbal medicines in worldwide. Present study describes that the formulation of the transdermal drug delivery that enhances the patient convenience and efficacy at the same time, as compared to the conventional drug delivery system like oral. This particular work aims at the transdermal drug delivery, the site of action being the inflammation at a particular part of the skin. For this we developed transdermal formulation (herbal gel) of an antimicrobial and anti-inflammatory agent extracts of flower of Chrysanthemum indicum. Chrysanthemum indicum is Ayurveda medicinal plant which has antimicrobial, anti-inflammatory, antioxidant activity and anticancer activity. The extraction of the Chrysanthemum indicum was done by the solvent extraction and Soxhlet extraction method and it is evaluated by various phytochemical and pharmacognostic studies. The extract was identified by the FTIR spectroscopic method which is known as the most preferred and superior technique for most analysis. The Chrysanthemum indicum extract was stabilized by using Carbopol, methyl paraben and propyl paraben. Stability studies were also performed on herbal gel that confirms that this formulation remains stable for 3 months. In-vivo and in vitro tests were also conducted for this herbal formulation. This herbal gel has been gone through the all necessary preformulation and evaluation studies that justifies that the efficacy of this transdermal drug delivery formulation (herbal gel) has shown its all activities that discussed above