Figure 1 from Functional Analysis of Rare RAS Variants of Unknown Significance

RAS protein domain and distribution of RAS mutations. A, RAS proteins comprise a G-domain consisting of five α-helix structures and six β-sheet structures, followed by a hypervariable region (HVR; 166–189 aa). The G-domain contains three GTP-binding domains and an effector-binding domain. The G-domain contains the P-loop (10–14 aa), switch I (30–40 aa), and Switch II (60–76 aa). B, Frequency of each cancer type associated with all mutations, canonical mutations, and noncanonical mutations in RAS, KRAS, NRAS, and HRAS, as observed in the C-CAT database. The values in each row represent percentages and sum to 100%, indicating the relative distribution of cancer types within each RAS mutation class. C, Frequency of each cancer type associated with codon-specific canonical and noncanonical RAS mutations, as observed in the C-CAT database. The values in each row represent percentages and sum to 100%, indicating the relative distribution of cancer types within each RAS mutation variant. D, Frequency of each RAS isoform among RAS mutations, as observed in the C-CAT database.