Case report reveals spindle activity in waking electroencephalogram of a glioblastoma patient, suggesting thalamus involvement.
Summary In this paper, we reported a patient with a hemispheric glioblastoma extending into the lateral thalamus and the posterior limb of the internal capsule. The waking electroencephalogram showed spindle activity on the side ipsilateral to the tumor. Based on the topography of the tumor in our patient, we speculate that a disruption of the synaptic pathways within the thalamus-cortex-thalamus circuit was primarily involved in the pathogenesis of abnormal spindling.
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Janatl et al. (1986) studied this question.
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