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October 2, 2025Middle East Fertility Society JournalOpen Access

Gene expression and demographic factors associated with endometriosis incidence: a landscape genetic approach

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Authors

HMHamidreza MahmoudiRazi HospitalPPParnian PamIslamic Azad University South Tehran BranchKJKimia JavidmehrIslamic Azad University South Tehran Branch

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Overview

Observational analysis found associations between gene expression and demographic factors in endometriosis cases, indicating geographic influence.

Key Points

  • Significant differences in gene expression were found between women with endometriosis and controls and were tied to demographic variables.
  • PPI interaction analysis revealed strong connections among target genes, suggesting potential biological pathways influencing the disease.
  • Multivariate methods like factor analysis highlighted gene variability as key in differentiating patients from controls, emphasizing genetic factors.
  • Redundancy analysis indicated geographical factors correlated with gene expression and SNP genotypes, reinforcing the complexity of endometriosis.

Cite This Study

Mahmoudi et al. (2025) studied this question.

synapsesocial.com/papers/68de79595b556a9128e1a3dahttps://doi.org/10.1186/s43043-025-00256-3
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