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Isolated Anterior T‐Wave Inversion in Elite Athletes: Prevalence and Clinical Relevance by Sex and Sporting Discipline

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Analysis reveals higher rates of isolated T-wave inversion in female athletes and endurance athletes, indicating different clinical considerations.

Isolated t-wave inversion was found in 36 athletes, notably more common in females and endurance athletes.
Female athletes had an isolated t-wave inversion prevalence of 1.5%, compared to 0.3% in male athletes, showing a significant difference.
Logistic regression analysis adjusted for sex and sporting discipline highlighted the clinical relevance of isolated t-wave inversion.
Despite higher prevalence in female athletes, no cases of cardiac disease were diagnosed during follow-up evaluations.

Orchard et al. (2025) studied this question.

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Analysis reveals higher rates of isolated T-wave inversion in female athletes and endurance athletes, indicating different clinical considerations.