This study demonstrates the antimicrobial effects of postbiotics from Pediococcus acidilactici against Staphylococcus aureus, suggesting their potential as alternative agents.
The increasing resistance of pathogenic bacteria to conventional antibiotics has necessitated the search for alternative antimicrobial agents. This study investigated the antimicrobial activity of postbiotic metabolites produced by Pediococcus acidilactici against Staphylococcus aureus (ATCC 13813™). The broth microdilution method determined the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the postbiotics. Additionally, the disk diffusion and well diffusion methods were employed to evaluate the antimicrobial activity. The results demonstrated that the postbiotic metabolites exhibited significant antimicrobial effects, with an MIC of 31.25 μg/mL and an MBC of 62.5 μg/mL. Inhibition zones of 8.33±0.58 a mm, 10.00±1.00 a mm, and 11.33±1.53 b mm were observed in the disk diffusion method at concentrations of 105, 125, and 145 μg/mL, respectively. In the well diffusion method, inhibition zones of 22.00±1.00 a mm, 26.00±1.00 b mm, 26.67±0.58 b mm, and 29.33±0.58 c mm were observed at concentrations of 125, 135, 145, and 155 μg/mL, respectively. These findings suggest that postbiotic metabolites from Pediococcus acidilactici have potential as alternative antimicrobial agents against Staphylococcus aureus.
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Ghaffari et al. (2025) studied this question.
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