Base-mediated annulation produces dicyanobenzene derivatives, indicating modularity in creating electron-deficient scaffolds.
We report a base‐mediated annulation of α‐EWG‐activated enone systems with 2,3‐dichloro‐5,6‐dicyanobenzoquinone (DDQ), affording dicyanobenzene derivatives via a sequential formal [4 + 2] cycloaddition and retrocyclization. In this process, DDQ acts as a dicyanoacetylene equivalent. The reaction is operationally simple and offers a modular route to electron‐deficient aromatic scaffolds.
No takes yet. Share an insight, caveat, or question.
Lee et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: