Answers are grounded in this paper and cite their sources.
A new strategy reports the synthesis of conjugated dienes in benzoquinone derivatives, suggesting new pathways for functionalization.
A new strategy for stepwise dearomative functionalization of catechols is presented. The key substrates, 1,2-benzoquinone monoximes derived from readily available catechols, could be converted to conjugated (Z,Z)-dienes and 2-cyanocyclopentadienones. This divergent synthesis was enabled through either trapping the acylium intermediates, which were generated by C-C bond cleavage of 1,2-benzoquinone monoximes, with nucleophiles or a subsequent intramolecular Friedel-Crafts acylation. Further transformations of previously unknown dearomatized products were then delineated.
No takes yet. Share an insight, caveat, or question.
Kim et al. (2026) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: