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October 2, 2025Stress and Health

Hsp70 and Hsp90 as Molecular Correlates of Anxiety in Children and Adolescents: The Role of Early‐Life Stress

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Authors

SKSeda KafalıSHSelma Tural HesapçıoğluMŞMehmet Emin Şeker

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Overview

Observational analysis reveals lower hsp70 and hsp90 in children with anxiety disorders, suggesting early-life stress impacts cellular stress response.

Key Points

  • Lower serum levels of hsp70 and hsp90 were found in children with anxiety disorders compared to healthy controls.
  • Hsp70 levels increased in children exposed to early-life stress, but less so in those with anxiety disorders.
  • Psychological stress appears linked to dysregulation of cellular stress-related mechanisms in anxiety disorders.
  • Further studies with additional markers are needed to validate the role of heat shock proteins in anxiety.

Cite This Study

Kafalı et al. (2025) studied this question.

synapsesocial.com/papers/68de84bb5b556a9128e1b87dhttps://doi.org/10.1002/smi.70109
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