The Green Metrics of Mechanoenzymatic Reactions

Mechanoenzymology is a green chemistry technology that has emerged in recent years, which can efficiently promote enzymatic hydrolysis reactions through mechanical force under low‐solvent conditions. Mechanoenzymatic reactions has the green metrics of reducing solvent usage, minimizing waste generation, potentially improving reaction efficiency, and mild reaction conditions, which conform to the Principles of Green Chemistry. In this review, the focus is on the latest research progress of mechanoenzymatic reactions and the green aspects based on the Principles of Green Chemistry. The challenges and prospects of mechanoenzymology are discussed to further promote its development and application.