Cobalt-catalyzed reaction efficiently synthesizes fluoroalkylated γ-lactones from unactivated alkenes, suggesting functional group tolerance.
A cobalt-catalyzed intramolecular fluoroalkylative carbonylation of unactivated alkenes has been developed, enabling the highly regioselective synthesis of fluoroalkylated γ-lactones in good yields. The mild reaction conditions exhibit good functional group tolerance, and the reaction can be performed on a large scale. Preliminary mechanistic investigations support a radical pathway in which a cationic acylcobalt(IV) complex is proposed as the key intermediate.
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Jiang et al. (2025) studied this question.
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