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October 2, 2025Journal of Clinical InvestigationOpen Access

SOX9 drives a stem-like transcriptional state and platinum resistance in high-grade serous ovarian cancer

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Authors

ADAlexander James DuvalFSFidan Seker-PolatMRMagdalena Rogozinska

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Overview

Multiomics reveals SOX9 regulates chemoresistance in high-grade serous ovarian cancer, highlighting cancer stem cells involvement.

Key Points

  • SOX9 drives a stem-like transcriptional state, increasing chemoresistance in high-grade serous ovarian cancer.
  • Epigenetic upregulation of SOX9 led to significant chemoresistance in multiple high-grade serous ovarian cancer lines.
  • Single-cell analysis revealed chemo treatment quickly induces SOX9 expression, enhancing a stem-like state.
  • These findings highlight SOX9 as a potential therapeutic target to combat chemoresistance in high-grade serous ovarian cancer.

Cite This Study

Duval et al. (2025) studied this question.

synapsesocial.com/papers/68de8eaeaa6cec72c69ea7cdhttps://doi.org/10.1172/jci186467
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Also Consider

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