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October 2, 2025Journal of Agricultural and Food Chemistry

Design, Synthesis, X-ray Crystal Structure, and Agricultural Antifungal Evaluation of Novel Benzohydrazide Derivatives Bearing the Quinazoline Moiety and a Piperazine Linker

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Authors

MYMingyan YiHLHong LiSLSha Li

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Overview

Synthesis of benzohydrazide derivatives shows strong antifungal activity against various fungi, indicating potential for agricultural use.

Key Points

  • Compound A16 exhibited a remarkable inhibition rate of 96% against multiple fungi, highlighting its effectiveness.
  • With an EC50 of 1.49 μg/mL against Rhizoctonia solani, A16 shows antifungal potency comparable to Boscalid.
  • The synthesis involved 32 novel benzohydrazide derivatives designed through a molecular hybridization approach.
  • Molecular docking simulations support the potential of A16 as a targeted inhibitor of fungal succinate dehydrogenase.

Cite This Study

Yi et al. (2025) studied this question.

synapsesocial.com/papers/68de8eaeaa6cec72c69ea7e9https://doi.org/10.1021/acs.jafc.5c08460
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