This method demonstrates broad applicability with good yields in hydrocarbation of allenes, indicating functional group tolerance.
The operatively simple Pd-catalyzed allene hydrocarbation described here uses HCO2Na and produces innocuous CO2 and sodium halide, and pure coupling products are isolated via water/ether extraction in most cases. This new transformation displays a broad C(sp2) halide scope, functional group tolerance, and good to excellent yields and allows inexpensive selective deuteration. Pd loadings of 0.10 mol % remain effective, and gram-scale reactions were conducted. The protocol extends to O-, N-, Si-, and C-substituted allenes, demonstrating its versatility.
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Perrault et al. (2025) studied this question.
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