October 3, 2025Nature CommunicationsOpen Access

Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1

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Analysis reveals cardiolipin modulates OPA1 activity and membrane remodeling in mitochondria, suggesting implications for Barth syndrome.

Cardiolipin significantly enhances the membrane remodeling activity of OPA1, impacting mitochondrial morphology.
Higher concentrations of monolyso-cardiolipin reduce OPA1-mediated membrane remodeling, highlighting potential dysfunction.
Molecular dynamics simulations show rich interactions between cardiolipin and the paddle domain of mitochondrial OPA1.
These findings indicate that cardiolipin replacement affects mitochondrial homeostasis, particularly in Barth syndrome.

Thatavarthy et al. (2025) studied this question.

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