Observational analysis shows transient bradykinesia improvements with DBS, suggesting plasticity can optimize treatment.
In a recent study, Spencer and colleagues demonstrated that high-frequency microsimulation of the globus pallidus internus (GPi) in individuals with Parkinson's disease induces long-term potentiation (LTP)-like effects in the inhibitory pathways, leading to transient improvements in bradykinesia that can persist beyond stimulation cessation. Their results highlight the potential of leveraging synaptic plasticity mechanisms in deep brain stimulation (DBS) to optimize therapy.
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Wang et al. (2025) studied this question.
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