October 3, 2025BMC CancerOpen Access

Olanzapine plus triple antiemetic therapy for prevention of carboplatin-induced nausea: a pooled analysis of two clinical trials

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Pooled analysis reveals olanzapine significantly reduces chemotherapy-induced nausea in patients, indicating its beneficial role in treatment.

Adding olanzapine to antiemetic therapy significantly reduced nausea rates compared to placebo, improving patient comfort.
In the olanzapine group, 87.5% experienced no nausea versus 75.0% in the placebo group, a significant difference of 12.5%.
Collected data from a pooled analysis of two distinct clinical trials supports the efficacy of olanzapine in this context.
The findings underscore the importance of olanzapine in managing nausea for patients undergoing carboplatin treatment.

Kojima et al. (2025) studied this question.

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October 3, 2025BMC CancerOpen Access

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Authors

Pooled analysis reveals olanzapine significantly reduces chemotherapy-induced nausea in patients, indicating its beneficial role in treatment.

Adding olanzapine to antiemetic therapy significantly reduced nausea rates compared to placebo, improving patient comfort.
In the olanzapine group, 87.5% experienced no nausea versus 75.0% in the placebo group, a significant difference of 12.5%.
Collected data from a pooled analysis of two distinct clinical trials supports the efficacy of olanzapine in this context.
The findings underscore the importance of olanzapine in managing nausea for patients undergoing carboplatin treatment.

Kojima et al. (2025) studied this question.

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