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This is a Experimental Study study.

October 3, 2025Microchimica ActaOpen Access

Proof-of-concept study of a CD-type microfluidic titration system with an ISFET sensor for microlitre-scale analysis

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Proof-of-concept study demonstrates automated acid-base titration in microlitre samples, suggesting advanced chemical analysis capabilities.

The microfluidic device showed reliable acid-base titration results using just 300 μL of sodium carbonate solution.
The ISFET sensor achieved a high sensitivity of 51.3 mV/pH and exceptional linearity across a broad pH range.
Rotation-driven fluid control enables precise reagent delivery, eliminating the need for external pumps or valves.
This system may enable portable, low-cost titration applications in marine biogeochemistry and point-of-care diagnostics.

Yang et al. (2025) studied this question.

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Proof-of-concept study demonstrates automated acid-base titration in microlitre samples, suggesting advanced chemical analysis capabilities.