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Resistance Exercise Intervention Restores Functional Capacity and Improves Frailty Biomarkers in Centenarians

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Intervention increases functional capacity and reduces frailty in centenarians, indicating potential health benefits.

Resistance exercise intervention significantly improved functional capacity and reduced frailty biomarkers in centenarians.
Post-intervention, SPPB scores improved from 2.3 to 5.0, while PPME scores rose from 3.8 to 6.5, demonstrating marked gains.
Participants showed varying expression of frailty and inflammation biomarkers, highlighting the physiological effects of age and exercise.
Correlation analyses revealed significant links between functional capacity and several biomarkers, emphasizing their interrelation in health.

Marcos-Pérez et al. (2025) studied this question.

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