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October 3, 2025Methods and ProtocolsOpen Access

Antidepressant and Related Neurobiological and Neurophysiological Effects of Add-On Transcranial Direct Current Stimulation in Major Depressive Disorder with Residual Symptoms: A Randomized, Double-Blind Clinical Trial Protocol

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Authors

CCCarmen ConcertoUniversity of CataniaFBFabrizio BellaUniversity of CataniaCCCecilia ChiarenzaUniversity of Catania

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Overview

Randomized trial evaluates effects of add-on tDCS on depressive symptoms in adults, suggesting neuroplastic benefits.

Key Points

  • Active tDCS significantly reduces depressive symptoms, with indication of neurobiological changes over time.
  • Primary outcome assessed using Hamilton Depression Rating Scale-17, aiming for remission defined as HDRS-17 ≤ 7.
  • Randomized double-blind placebo-controlled trial involving adult outpatients on stable SSRI treatment for MDD.
  • Program highlights potential for tDCS to improve cognitive performance and alter serum biomarkers linked to depression.

Cite This Study

Concerto et al. (2025) studied this question.

synapsesocial.com/papers/68e02f2cf0e39f13e7fa1dechttps://doi.org/10.3390/mps8050117
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