October 3, 2025BMC MedicineOpen Access

Investigating the relationship of plasma microRNAs and colorectal cancer risk using genetic evidence

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Discussion

Mendelian randomization reveals associations of selected microRNAs with colorectal cancer risk, suggesting potential pathways.

Five microRNAs are significantly associated with colorectal cancer risk according to Mendelian randomization.
Specifically, miR-146a-5p, miR-21-5p, and miR-4707-3p show positive associations, while miR-1908-5p and miR-6810-3p show inverse associations.
The analysis utilized Mendelian randomization and colocalization on 58,221 colorectal cancer cases and 67,694 controls.
Findings highlight potential preventive targets, aligning with genetic evidence and downstream biological pathways.

Bouras et al. (2025) studied this question.

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