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October 3, 2025BMC CancerOpen Access

Early circulating EBV-DNA clearance predicts enhanced short-term treatment response and survival benefit in locally advanced nasopharyngeal carcinoma

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Authors

XLXin LuUniversity of Notre DameLZLing ZhuSichuan Agricultural UniversityBTBibo TanHebei Medical University

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Implication

This analysis reveals that early clearance of ebv-dna improves treatment response and survival outcomes in patients with locally advanced nasopharyngeal carcinoma.

Key Points

  • Early clearance of ebv-dna was linked to significantly greater tumor volume reduction and improved survival outcomes.
  • The study analyzed 173 patients with locally advanced nasopharyngeal carcinoma over a period from January 2018 to October 2022.
  • Retrospective analysis utilized correlation assessments and survival outcome evaluations, with significant findings for overall and progression-free survival.
  • Independent risk factors for poor prognosis included smoking, poor tumor response, and lack of targeted therapy or immunotherapy.

Cite This Study

Lu et al. (2025) studied this question.

synapsesocial.com/papers/68e02f34f0e39f13e7fa20d9https://doi.org/10.1186/s12885-025-14888-1
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