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October 3, 2025BMC MicrobiologyOpen Access

Comprehensive evaluation of the bactericidal and anti-pathogenic efficacy of chemical disinfectants against antibiotic resistant ESKAPE clinical strains

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Authors

MMMihaela Magdalena MitacheTitu Maiorescu UniversityAPAndreea PîndaruUniversity of BucharestIBIlda Czobor BarbuUniversity of Bucharest

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Implication

This evaluation quantifies disinfectant efficacy against antibiotic resistant ESKAPE pathogens, suggesting critical contact and concentration levels.

Key Points

  • All disinfectants achieved at least 5 log₁₀ reductions under specified conditions, but efficacy decreased significantly with reduced contact time or dilution.
  • Hydrogen-peroxide showed reduced efficacy against clinical E. faecium and Pseudomonas strains compared to reference strains, highlighting the importance of concentration.
  • Sub-lethal concentrations of chlorine and hydrogen peroxide significantly reduced biofilm biomass and inhibited virulence factors, enhancing their antimicrobial effects.
  • Adherence to manufacturer-specified disinfectant conditions is vital to prevent survival of MDR ESKAPE pathogens during cleaning protocols.

Cite This Study

Mitache et al. (2025) studied this question.

synapsesocial.com/papers/68e02f34f0e39f13e7fa2117https://doi.org/10.1186/s12866-025-04273-0
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