What type of study is this?

This is a Case-Control Study study.

October 3, 2025Clinical and Translational GastroenterologyOpen Access

Fecal Microbiota and Bile Acid Profiles in Early-Stage Hepatocellular Carcinoma: A Matched Case-Control Study

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Authors

YNYael R. NobelColumbia University Irving Medical Center HPHeekuk ParkUniversidade Federal de Rondônia ATAlice TillmanNYU Langone Health

Discussion

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Implication

Matched case-control study reveals limited differences in microbiota and bile acid profiles between HCC and cirrhosis patients, suggesting further research needed.

Key Points

Increased concentration of secondary bile acids was associated with higher odds of hepatocellular carcinoma.
In the study of 98 patients, the prevalence of Hepatitis C was significantly higher in those with HCC.
The case-control study found limited differences in microbiota composition between patients with cirrhosis and early-stage HCC.
Differential abundance of taxa like Klebsiella pneumoniae was noted in cases, indicating potential biomarkers.

Cite This Study

Nobel et al. (2025) studied this question.

synapsesocial.com/papers/68e02f34f0e39f13e7fa225e https://doi.org/10.14309/ctg.0000000000000928

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October 3, 2025Clinical and Translational GastroenterologyOpen Access

Fecal Microbiota and Bile Acid Profiles in Early-Stage Hepatocellular Carcinoma: A Matched Case-Control Study

View Full Paper

Ask AI

Bookmark

Authors

YNYael R. NobelColumbia University Irving Medical Center HPHeekuk ParkUniversidade Federal de Rondônia ATAlice TillmanNYU Langone Health

Discussion

Member takes

Implication

Matched case-control study reveals limited differences in microbiota and bile acid profiles between HCC and cirrhosis patients, suggesting further research needed.

Key Points

Increased concentration of secondary bile acids was associated with higher odds of hepatocellular carcinoma.
In the study of 98 patients, the prevalence of Hepatitis C was significantly higher in those with HCC.
The case-control study found limited differences in microbiota composition between patients with cirrhosis and early-stage HCC.
Differential abundance of taxa like Klebsiella pneumoniae was noted in cases, indicating potential biomarkers.

Cite This Study

Nobel et al. (2025) studied this question.

synapsesocial.com/papers/68e02f34f0e39f13e7fa225e https://doi.org/10.14309/ctg.0000000000000928

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