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This review examines depot injections' formulation strategies and clinical applications, highlighting their potential in chronic disease management.
Depot injections represent a pivotal advancement in sustained and controlled drug delivery systems, offering prolonged therapeutic effects, enhanced patient compliance, and reduced dosing frequency. This review comprehensively examines the formulation strategies, mechanisms of drug release, clinical applications, and recent innovations in depot injection technologies. Polymeric matrices, lipid-based systems, and in situ forming depots are discussed alongside their pharmacokinetic and pharmacodynamic implications. Furthermore, the challenges associated with manufacturing, stability, and regulatory considerations are addressed. With over 45 referenced studies, this paper highlights the transformative potential of depot injections in treating chronic diseases, hormonal disorders, and psychiatric conditions while identifying future research directions for optimizing their efficacy and safety.
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Mahajan et al. (2025) studied this question.
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