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May 25, 2026Journal of Biomaterials Science Polymer Edition

Thermoresponsive injectable sol-gel depot systems for long-acting antidiabetic drug delivery: a critical analysis of polymer chemistry, rheological engineering, and translational challenges

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Authors

GRGulshan RathoreRSRavindra Pal Singh

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Overview

This review critically analyzes thermoresponsive systems for sustained drug release in type 2 diabetes, suggesting implications for advanced therapies.

Key Points

  • The aim is to explore the development and challenges of thermoresponsive sol-gel systems for antidiabetic drug delivery.
  • Critical analysis of polymer chemistry, rheological behavior, and polymer-drug interactions.
  • Evaluation of LCST behavior of various polymers including PEG-PLGA-PEG and Pluronic.
  • Assessment of translation challenges such as burst release and thermomechanical instability.
  • The use of thermoresponsive systems can provide near zero-order drug release over a prolonged period.
  • Challenges relating to immunogenicity and regulatory limitations remain a significant focus.
  • New formulations incorporating nanoparticles and glucose-powered hydrogels show promise in improving therapeutic outcomes.

Cite This Study

Rathore et al. (2026) studied this question.

synapsesocial.com/papers/6a13e8030e02ee3982d32b24https://doi.org/10.1080/09205063.2026.2675316
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Injectable thermosensitive hydrogel-based sustained delivery system for anti-diabetic peptides in type 2 diabetes mellitus therapy: A review2026
  2. 2Advanced Transdermal Systems for Non-Invasive Delivery of GLP-1 Agonists in Treatment of Diabetes2026
  3. 3Injectable Thermoresponsive Hydrogels for Localized Drug Delivery: Mechanisms, In Vivo Evidence and Translational Challenges2026
  4. 4DESIGN AND EVALUATION OF TRANSDERMAL SYSTEMS: A REVIEW OF EMERGING APPROACHES2026
  5. 5ADVANCED ORAL DRUG DELIVERY PLATFORMS FOR TYPE 2 DIABETES MELLITUS: BRIDGING PHARMACOKINETIC CHALLENGES AND GLYCAEMIC OUTCOMES2026