This review demonstrates improved glycemic control and body-weight management in type 2 diabetes using thermosensitive hydrogels, suggesting a new therapeutic approach.
Key Points
The aim is to review the role of injectable thermosensitive hydrogels in delivering anti-diabetic peptides for type 2 diabetes mellitus therapy.
Reviewed classification and polymer composition of thermosensitive hydrogels
Evaluated drug release mechanisms
Summarized clinical implications of hydrogels in diabetes management
Thermosensitive hydrogels enable sustained drug release and improved glycemic control
GLP-1 receptor agonists in these systems show significant body-weight reduction
Enhanced patient adherence and reduced injection frequency compared to conventional therapies